Geriatrics
Basic FGF attenuates amyloid beta-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons.
Mark RJ; Keller JN; Kruman I; Mattson MP
Sanders-Brown Research Center on Aging, University of Kentucky, Lexington 40536, USA.
Brain Res, 756(1-2):205-14 1997 May 9
Abstract
Basic fibroblast growth factor (bFGF) exhibits trophic activity for many populations of neurons in the brain, and can protect those neurons against excitotoxic, metabolic and oxidative insults. In Alzheimer’s disease (AD), amyloid beta-peptide (A beta) fibrils accumulate in plaques which are associated with degenerating neurons.
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MESH Headings
Amyloid beta-Protein *PD ; Animal ; Fibroblast Growth Factor, Basic *PD ; Hippocampus CY/*ME ; Hydrogen Peroxide ME ; Lipid Peroxides ME ; Mitochondria DE/PH ; Na(+)-K(+)-Exchanging ATPase *ME NA K EXCHANGING ATPASE ; Neurons *ME ; Neurotoxins AI ; Oxidative Stress *DE ; Rats EM ; Support, Non-U.S. Gov’t ; Support, U.S. Gov’t, P.H.S.
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JOURNAL ARTICLE
